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Substance P

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (2) Amino Acid Derivatives (1) Antibiotic (2) Apoptosis (3) Bacterial (1) Bombesin Receptor (1) Cholinesterase (ChE) (1) Cytochrome P450 (3) Dopamine β-hydroxylase (2) Endogenous Metabolite (3) Influenza Virus (2) Interleukin Related (1) Isotope-Labeled Compounds (1) JNK (1) mAChR (3) Monoamine Oxidase (2) Neurokinin Receptor (56) Neuropeptide Y Receptor (1) p38 MAPK (1) PACAP Receptor (2) PKC (2) Reverse Transcriptase (2) Telomerase (2)
By Research Areas:	Cancer (9) Cardiovascular Disease (1) Endocrinology (20) Infection (3) Inflammation/Immunology (17) Metabolic Disease (2) Neurological Disease (61)

By Targets:

Adrenergic Receptor (2)

Amino Acid Derivatives (1)

Antibiotic (2)

Apoptosis (3)

Bacterial (1)

Bombesin Receptor (1)

Cholinesterase (ChE) (1)

Cytochrome P450 (3)

Dopamine β-hydroxylase (2)

Endogenous Metabolite (3)

Influenza Virus (2)

Interleukin Related (1)

Isotope-Labeled Compounds (1)

JNK (1)

mAChR (3)

Monoamine Oxidase (2)

Neurokinin Receptor (56)

Neuropeptide Y Receptor (1)

p38 MAPK (1)

PACAP Receptor (2)

PKC (2)

Reverse Transcriptase (2)

Telomerase (2)

By Research Areas:

Cancer (9)

Cardiovascular Disease (1)

Endocrinology (20)

Infection (3)

Inflammation/Immunology (17)

Metabolic Disease (2)

Neurological Disease (61)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Substance P 15+ Cited Publications Neurokinin P	Neurokinin Receptor Endogenous Metabolite	Neurological Disease Endocrinology Cancer
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

Substance P (4-11)	Neurokinin Receptor	Neurological Disease
Substance P (4-11), the C-terminus fragment of Substance P (Substance P (HY-P0201)), is a Substance P agonist that shows highly selective for NK1 receptors .

Substance P (alligator)	Neurokinin Receptor Endogenous Metabolite	Neurological Disease
Substance P (alligator), a Substance P (Substance P (HY-P0201)) extracted from alligator, is a neuropeptide. The primary structure of Substance P (alligator) is: Arg-Pro-Arg-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 .

Substance P (6-11)	Neurokinin Receptor	Neurological Disease
Substance P (6-11) is the C-terminal hexapeptideamide of Substance P (Substance P (HY-P0201)). Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect .

Substance P (5-11)	Neurokinin Receptor	Neurological Disease
Substance P (5-11), the C-terminal heptapeptide of Substance P (Substance P (HY-P0201)), is a neuropeptide. Substance P (5-11) binds to NK-1 tachykinin receptor .

Substance P(1-7)	Neurokinin Receptor	Neurological Disease Endocrinology
Substance P(1-7) is a fragment of the neuropeptide, substance P (SP). Substance P(1-7) gives depressor and bradycardic effects when applied to the nucleus tractus solitarius .

Substance P (5-11) (TFA)	Neurokinin Receptor	Neurological Disease
Substance P (5-11) TFA TFA, the C-terminal heptapeptide of Substance P (Substance P (HY-P0201)), is a neuropeptide. Substance P (5-11) TFA TFA binds to NK-1 tachykinin receptor .

Substance P-Gly-Lys-Arg	Neurokinin Receptor	Neurological Disease
Substance P-Gly-Lys-Arg, also known as β-Preprotachykinin (58-71), is an analog of Substance P (Substance P (HY-P0201)) .

Substance P (1-9)	Neurokinin Receptor	Neurological Disease
Substance P (1-9) is nonapeptide, which decreases the inactivation of substance P by the guinea-pig ileum and urinary bladder.

Substance P (7-11)	Neurokinin Receptor	Neurological Disease Endocrinology
Substance P (7-11) is a C-terminal fragment of Substance P which can cause an increase in the intracellular calcium concentration.

Substance P(1-7) TFA	Neurokinin Receptor	Neurological Disease Endocrinology
Substance P(1-7) TFA is a fragment of the neuropeptide, substance P (SP). Substance P(1-7) TFA gives depressor and bradycardic effects when applied to the nucleus tractus solitarius .

Substance P TFA 15+ Cited Publications Neurokinin P TFA	Neurokinin Receptor Endogenous Metabolite	Neurological Disease Endocrinology Cancer
Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R) .

Substance P Receptor Antagonist 1	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
Substance P Receptor Antagonist 1 has the potential function in central nervous system disorders, respiratory, inflammatory diseases and gastrointestinal disorders.

*[His11]Substance* P**	Neurokinin Receptor	Neurological Disease
[His11]Substance P is an analog of Substance P (Substance P (HY-P0201)).Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS .

*[Gly11] Substance* P**	Neurokinin Receptor	Neurological Disease
[Gly11] Substance P is an analog of Substance P (Substance P (HY-P0201)).Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS .

*[MePhe8,Sar9] Substance* P** [MePhe8-MeGly9] Substance P	Neurokinin Receptor	Neurological Disease
[MePhe8,Sar9] Substance P ([MePhe8-MeGly9] Substance P) is an analog of Substance P (Substance P (HY-P0201)).Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS .

*[D-Trp7,9,10]-Substance* P TFA**	mAChR	Endocrinology
[D-Trp7,9,10]-Substance P TFA is a substance P analogue. Substance P stimulates substance P receptors but also inhibits ion conductance through nicotinic acetylcholine receptors .

*[Tyr8,Nle11] Substance* P**	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
[Tyr8,Nle11] Substance P is a Substance P (HY-P0201) analog. Substance P is a peptide mainly secreted by neurons and is involved in many biological processes, including nociception and inflammation .

*[DAla4] Substance* P (4-11)**	Neurokinin Receptor	Neurological Disease
[DAla4] Substance P (4-11) is an analog of Substance P (Substance P (HY-P0201)) that inhibits the binding of ¹²⁵I-Bolton Hunter-conjugated Eledoisin (Eledoisin (HY-P0006)) (IC₅₀ of 0.5 μM) and ¹²⁵I-Bolton Hunter-conjugated Substance P (IC₅₀ of 0.15 μM) to rat brain cortex membranes .

*[Pro9]-Substance* P**	Neurokinin Receptor	Neurological Disease
[Pro9]-Substance P is a potent, reversible and selective agonist of NK-1 tachykinin receptors with an EC₅₀ of 0.93 nM .

*[Glp5] Substance* P (5-11)**	Neurokinin Receptor	Neurological Disease Endocrinology
[Glp5] Substance P (5-11) is an octapeptide. [Glp5] Substance P (5-11) is one of the main substance P fragments in rat central nervous system (CNS). [Glp5] Substance P (5-11) locally modulates dopamine release in rat striatum .

*[D-Pro2,D-Trp7,9] Substance* P**	Neurokinin Receptor	Inflammation/Immunology
[D-Pro2,D-Trp7,9] Substance P, a Substance P (HY-P0201) analogue, is a weak agonist and a potent, specific, competitive Substance P antagonist .

*Biotin-Substance* P**	Neurokinin Receptor	Neurological Disease
Biotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R) .

*[Nle11]-Substance* P**	Neurokinin Receptor	Neurological Disease Endocrinology
[Nle11]-Substance P is a substance P analog that avoids methionine oxidation problems.

*[Sar4] Substance* P (4-11)**	Neurokinin Receptor	Neurological Disease
[Sar4] Substance P (4-11) is an analog of Substance P (4-11). Substance P (4-11), the C-terminus fragment of Substance P (Substance P (HY-P0201)), is a Substance P agonist .

*[Glp6] Substance* P (6-11)**	Neurokinin Receptor	Neurological Disease
[Glp6] Substance P (6-11) is an analogue of substance P (6-11). Substance P (6-11) stimulates [3H]-inositol monophosphate ([3H]-IP1) formation in rat urinary bladder by acting on the 'septide-sensitive' tachykinin receptors .

Benzomalvin B	Neurokinin Receptor	Others
Benzomalvin B is the less active analogs of Benzomalvin A. Benzomalvin B is weakly active against substance P .

Ditryptophenaline (-)-Ditryptophenaline	Neurokinin Receptor	Inflammation/Immunology
Ditryptophenaline ((-)-Ditryptophenaline) is the metabolites of Aspergillus flavus. Ditryptophenaline inhibits substance P receptor and has anti-inflammatory activity .

*[Sar9] Substance* P**	Neurokinin Receptor	Neurological Disease Endocrinology
[Sar9] Substance P is a potent and selective neurokinin (NK)-1 receptor agonist .

*[Glp5,Sar9] Substance* P (5-11)**	Neurokinin Receptor	Neurological Disease
[Glp5,Sar9] Substance P (5-11) is an analogue of Substance P (HY-P0201) .

Septide (Pyr6,Pro9)-Substance P	Neurokinin Receptor	Neurological Disease
Septide ((Pyr6,Pro9)-Substance P) is a potent NK1 receptor agonist with a K_d value of 0.55 nM .

*[Sar9,Met(O2)11]-Substance* P**	Neurokinin Receptor	Neurological Disease Endocrinology
[Sar9,Met(O2)11]-Substance P is a tachykinin NK₁ receptor selective agonist.

*[Sar9,Met(O2)11]-Substance* P TFA**	Neurokinin Receptor	Neurological Disease Endocrinology
[Sar9,Met(O2)11]-Substance P TFA is a tachykinin NK₁ receptor selective agonist.

Neurokinin Receptor (393-407), rat SPR393-407	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
Neurokinin Receptor (393-407), rat (SPR393–407) is a rat neurokinin 1 receptor (NK1R) fragment. NK1R is rapidly internalized by endocytosis and recycled to the plasma membrane when binding to substance P (SP). Neurokinin Receptor (393-407), rat can be used in the research of neurogenic inflammation .

*[D-Pro4,D-Trp7,9,Nle11] Substance* P (4-11)**	Neurokinin Receptor	Cardiovascular Disease Neurological Disease
[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) is a potent neurokinin NK1 antagonist. [D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) inhibits the effects of gold-protein-substance P (GPSP) and substance P (SP) .

CP-96,345	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
CP-96,345 is a specific, highly potent, and orally active tachykinin and substance P receptor non-peptide inhibitor. CP-96,345 prevents the drop in blood pressure evoked by substance P and neurokinin A. CP-96,345 can be used for researching neurogenic inflammation .

RP 67580	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
RP 67580 is a non-peptide antagonist of substance P (SP), competitively inhibits the binding of [3H]SP to neurokinin receptor 1 (NK1 receptor) in rat brain membranes with a K_i value of 4.16 nM. RP 67580 is a specific antagonist of NK1 receptors and can be used in the research of pain and neurogenic inflammation .

*(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance* P**	Neurokinin Receptor	Neurological Disease
(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P is a neuropeptide Substance P (HY-P0201) antagonist .

*[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance* P**	JNK Interleukin Related Bombesin Receptor	Inflammation/Immunology Cancer
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P, a Substance P derivative, is a biased agonist toward neuropeptide and chemokine receptors. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P activates G12. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P binds to IL-8 and GRP receptors. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P inhibits ERK-2 activation, activates JNK activity. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P stimulates an increase in neutrophil migration and Ca ²⁺ mobilization. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is also a bombesin antagonist, and inhibits the growth of small cell lung cancer

Spantide II	Neurokinin Receptor	Inflammation/Immunology
Spantide II, an undecapeptide substance P (SP) analog, is a potent neurokinin-1 receptor (NK-1R) antagonist. Spantide II binds with NK-1R and blocks proinflammatory activities associated with SP. Spantide II can be used in the research of inflammatory skin disorders, such as psoriasis and contact dermatitis .

(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B	Neurokinin Receptor	Neurological Disease
(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B is a competitive antagonist of Neurokinin B (Neurokinin Receptor) with a pA2 of 5.5. (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B shows no influence on Substance P or Neurokinin A .

G-Protein antagonist peptide	mAChR Adrenergic Receptor	Endocrinology
G-Protein antagonist peptide is the substance P-related peptide that inhibits binding of G proteins to their receptors. G-Protein antagonist peptide competitively and reversibly inhibits M2 muscarinic receptor activation of G_i or G_o and inhibits G_s activation by β-adrenoceptors.

*[Glp5,(Me)Phe8,Sar9] Substance* P (5-11)** DiMe-C7	Neurokinin Receptor	Others Neurological Disease Metabolic Disease
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats .

Galantide	Neuropeptide Y Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology
Galantide, a non-specific galanin receptor antagonist, is a peptide consisting of fragments of galanin and substance P. Galantide recognizes two classes of galanin binding sites (K_D<0.1 nM and ~6 nM) in the rat hypothalamus. Galantide dose dependently (IC₅₀=1.0 nM) antagonizes the galanin-mediated inhibition of the glucose-induced insulin secretion from mouse pancreatic islets. Galantide appears to bind to a single population of SP receptors (K_D~40 nM) .

*[D-Trp2,7,9] Substance* P**	Neurokinin Receptor	Neurological Disease
[D-Trp2,7,9] Substance P is a tachykinin (Neurokinin Receptor) antagonist with K_i values of 1 μM, 1.3 μM, and ~9 μM for NK-1, NK-2,and NK-3 receptor, respectively .

*(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance* P**	Neurokinin Receptor	Neurological Disease
(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P is a selective NK₁ receptor antagonist .

Cat. No.	Product Name	Type

HY-Y0320

Dimethyl sulfoxide

85+ Cited Publications

DMSO

Co-solvents

Dimethyl sulfoxide (DMSO) is an aprotic solvent that dissolves polar and non-polar compounds, including water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and can rapidly penetrate or enhance the penetration of other substances into biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity. Dimethyl sulfoxide also exhibits antifreeze and antibacterial properties .
MCE provides Dimethyl sulfoxide that complies with the inspection standards (Ch.P) of Part 4 of the Chinese Pharmacopoeia (2020 Edition).

Cat. No.	Product Name	Target	Research Area

HY-P0201

Substance P 15+ Cited Publications Neurokinin P	Neurokinin Receptor Endogenous Metabolite	Neurological Disease Endocrinology Cancer
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

HY-P3891

Substance P (4-11)	Neurokinin Receptor	Neurological Disease
Substance P (4-11), the C-terminus fragment of Substance P (Substance P (HY-P0201)), is a Substance P agonist that shows highly selective for NK1 receptors .

HY-P3895

Substance P (3-11)	Peptides	Neurological Disease
Substance P (3-11) is a substance P (SP) fragment peptide that can cross the BBB. Substance P (3-11) has contracting activities on guinea pig ileum. Substance P (3-11) also promotes human monocyte chemotaxis .

HY-P1498

Substance P, Free Acid

Peptides Neurological Disease

Substance P, Free Acid is a native substance P analog, but shows no biological activity of substance P.

HY-P3885

Substance P (alligator)	Neurokinin Receptor Endogenous Metabolite	Neurological Disease
Substance P (alligator), a Substance P (Substance P (HY-P0201)) extracted from alligator, is a neuropeptide. The primary structure of Substance P (alligator) is: Arg-Pro-Arg-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 .

HY-P3889

Substance P (6-11)	Neurokinin Receptor	Neurological Disease
Substance P (6-11) is the C-terminal hexapeptideamide of Substance P (Substance P (HY-P0201)). Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect .

HY-P3890

Substance P (5-11)	Neurokinin Receptor	Neurological Disease
Substance P (5-11), the C-terminal heptapeptide of Substance P (Substance P (HY-P0201)), is a neuropeptide. Substance P (5-11) binds to NK-1 tachykinin receptor .

HY-P3896

Substance P (2-11)	Peptides	Neurological Disease
Substance P (2-11) is a substance P (SP) fragment peptide. Substance P (2-11) has contracting activities on guinea pig ileum. Substance P (2-11) inhibits the permeation of ³H SP in BBMEC monolayers .

HY-P1485

Substance P(1-7)	Neurokinin Receptor	Neurological Disease Endocrinology
Substance P(1-7) is a fragment of the neuropeptide, substance P (SP). Substance P(1-7) gives depressor and bradycardic effects when applied to the nucleus tractus solitarius .

HY-P3890A

Substance P (5-11) (TFA)	Neurokinin Receptor	Neurological Disease
Substance P (5-11) TFA TFA, the C-terminal heptapeptide of Substance P (Substance P (HY-P0201)), is a neuropeptide. Substance P (5-11) TFA TFA binds to NK-1 tachykinin receptor .

HY-P3886

Substance P-Gly-Lys-Arg	Neurokinin Receptor	Neurological Disease
Substance P-Gly-Lys-Arg, also known as β-Preprotachykinin (58-71), is an analog of Substance P (Substance P (HY-P0201)) .

HY-P1494

Substance P (1-9)	Neurokinin Receptor	Neurological Disease
Substance P (1-9) is nonapeptide, which decreases the inactivation of substance P by the guinea-pig ileum and urinary bladder.

HY-P1492

Substance P (7-11)	Neurokinin Receptor	Neurological Disease Endocrinology
Substance P (7-11) is a C-terminal fragment of Substance P which can cause an increase in the intracellular calcium concentration.

HY-P1485A

Substance P(1-7) TFA	Neurokinin Receptor	Neurological Disease Endocrinology
Substance P(1-7) TFA is a fragment of the neuropeptide, substance P (SP). Substance P(1-7) TFA gives depressor and bradycardic effects when applied to the nucleus tractus solitarius .

HY-W344602

Substance P, [Met-OMet11]	Peptides	Others
Substance P, [Met-OMet11] is a selective *SP-P* agonist. Substance P, [Met-OMet11] also is an active peptide. Substance P, [Met-OMet11] can be used for various biochemical studies .

HY-P3598

Substance P(1-4)	Peptides	Cancer
Substance P(1-4) is a potent neurokinin receptors (NK-R) antagonist. Substance P(1-4) has regulation of normal hematopoiesis and inhibits endogenous erythroid colony (EEC) formation .

HY-P0201A

Substance P TFA 15+ Cited Publications Neurokinin P TFA	Neurokinin Receptor Endogenous Metabolite	Neurological Disease Endocrinology Cancer
Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R) .

HY-P0201F

Substance P, FAM-labeled

Peptides Others

Substance P, FAM-labeled is a biological active peptide. (FAM labeled HY-P0201)

HY-P3925

*[His11]Substance* P**	Neurokinin Receptor	Neurological Disease
[His11]Substance P is an analog of Substance P (Substance P (HY-P0201)).Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS .

HY-P3922

*[Gly11] Substance* P**	Neurokinin Receptor	Neurological Disease
[Gly11] Substance P is an analog of Substance P (Substance P (HY-P0201)).Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS .

HY-P3927

*[MePhe8,Sar9] Substance* P** [MePhe8-MeGly9] Substance P	Neurokinin Receptor	Neurological Disease
[MePhe8,Sar9] Substance P ([MePhe8-MeGly9] Substance P) is an analog of Substance P (Substance P (HY-P0201)).Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS .

HY-P1375

*[D-Trp7,9,10]-Substance* P**	Peptides	Endocrinology
[D-Trp7,9,10]-Substance P is a substance P analogue. Substance P stimulates substance P receptors but also inhibits ion conductance through nicotinic acetylcholine receptors .

HY-P1375A

*[D-Trp7,9,10]-Substance* P TFA**	mAChR	Endocrinology
[D-Trp7,9,10]-Substance P TFA is a substance P analogue. Substance P stimulates substance P receptors but also inhibits ion conductance through nicotinic acetylcholine receptors .

HY-P3933

*[Tyr8,Nle11] Substance* P**	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
[Tyr8,Nle11] Substance P is a Substance P (HY-P0201) analog. Substance P is a peptide mainly secreted by neurons and is involved in many biological processes, including nociception and inflammation .

HY-P3883

*[DAla4] Substance* P (4-11)**	Neurokinin Receptor	Neurological Disease
[DAla4] Substance P (4-11) is an analog of Substance P (Substance P (HY-P0201)) that inhibits the binding of ¹²⁵I-Bolton Hunter-conjugated Eledoisin (Eledoisin (HY-P0006)) (IC₅₀ of 0.5 μM) and ¹²⁵I-Bolton Hunter-conjugated Substance P (IC₅₀ of 0.15 μM) to rat brain cortex membranes .

HY-P3820

*[Dehydro-Pro4] Substance* P (4-11)**	Peptides	Neurological Disease Inflammation/Immunology
[Dehydro-Pro4] Substance P (4-11) is a peptide fragment of Substance P. Substance P is a peptide mainly secreted by neurons. Substance P takes part in many biological processes, including nociception, inflammation and immunity .

HY-P2475

[Pro9]-Substance P

Neurokinin Receptor Neurological Disease

[Pro9]-Substance P is a potent, reversible and selective agonist of NK-1 tachykinin receptors with an EC₅₀ of 0.93 nM .

HY-P3800

*[Glp5] Substance* P (5-11)**	Neurokinin Receptor	Neurological Disease Endocrinology
[Glp5] Substance P (5-11) is an octapeptide. [Glp5] Substance P (5-11) is one of the main substance P fragments in rat central nervous system (CNS). [Glp5] Substance P (5-11) locally modulates dopamine release in rat striatum .

HY-P3809

*[D-Pro2,D-Phe7,D-Trp9] Substance* P**	Peptides	Neurological Disease
[D-Pro2,D-Phe7,D-Trp9] Substance P is a Substance P (HY-P0201) analogue. [D-Pro2,D-Phe7,D-Trp9] Substance P is an inhibitor of Substance P. [D-Pro2,D-Phe7,D-Trp9] Substance P contracts guinea-pig ileum (GPI) indirectly .

HY-P3808

*[D-Pro2,D-Trp7,9] Substance* P**	Neurokinin Receptor	Inflammation/Immunology
[D-Pro2,D-Trp7,9] Substance P, a Substance P (HY-P0201) analogue, is a weak agonist and a potent, specific, competitive Substance P antagonist .

HY-P2546

*Biotin-Substance* P**	Neurokinin Receptor	Neurological Disease
Biotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R) .

HY-P1506

[Nle11]-Substance P

Neurokinin Receptor Neurological Disease Endocrinology

[Nle11]-Substance P is a substance P analog that avoids methionine oxidation problems.
HY-P2784

[Tyr8]-Substance P

Peptides Others

[Tyr8]-Substance P is an active peptide. [Tyr8]-Substance P can be used for the research of various biochemical .

HY-P3932

*[Sar4] Substance* P (4-11)**	Neurokinin Receptor	Neurological Disease
[Sar4] Substance P (4-11) is an analog of Substance P (4-11). Substance P (4-11), the C-terminus fragment of Substance P (Substance P (HY-P0201)), is a Substance P agonist .

HY-P3799

*[Glp6] Substance* P (6-11)**	Neurokinin Receptor	Neurological Disease
[Glp6] Substance P (6-11) is an analogue of substance P (6-11). Substance P (6-11) stimulates [3H]-inositol monophosphate ([3H]-IP1) formation in rat urinary bladder by acting on the 'septide-sensitive' tachykinin receptors .

HY-P1738

[Sar9] Substance P

Neurokinin Receptor Neurological Disease Endocrinology

[Sar9] Substance P is a potent and selective neurokinin (NK)-1 receptor agonist .
HY-P3905

[Glp5,Sar9] Substance P (5-11)

Neurokinin Receptor Neurological Disease

[Glp5,Sar9] Substance P (5-11) is an analogue of Substance P (HY-P0201) .
HY-P2000

Septide

(Pyr6,Pro9)-Substance P
Neurokinin Receptor Neurological Disease

Septide ((Pyr6,Pro9)-Substance P) is a potent NK1 receptor agonist with a K_d value of 0.55 nM .
HY-P1012

[Sar9,Met(O2)11]-Substance P

Neurokinin Receptor Neurological Disease Endocrinology

[Sar9,Met(O2)11]-Substance P is a tachykinin NK₁ receptor selective agonist.
HY-P1012A

[Sar9,Met(O2)11]-Substance P TFA

Neurokinin Receptor Neurological Disease Endocrinology

[Sar9,Met(O2)11]-Substance P TFA is a tachykinin NK₁ receptor selective agonist.

HY-P3852

Neurokinin Receptor (393-407), rat SPR393-407	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
Neurokinin Receptor (393-407), rat (SPR393–407) is a rat neurokinin 1 receptor (NK1R) fragment. NK1R is rapidly internalized by endocytosis and recycled to the plasma membrane when binding to substance P (SP). Neurokinin Receptor (393-407), rat can be used in the research of neurogenic inflammation .

HY-P3803

*[D-Pro4,D-Trp7,9] Substance* P (4-11)**	Peptides	Neurological Disease
[D-Pro4,D-Trp7,9] Substance P (4-11) is a potent antagonist of Substance P (HY-P0201). [D-Pro4,D-Trp7,9] Substance P (4-11) decreases plasma aldosterone (ALDO) concentration .

HY-P3805

*[D-Pro4,D-Trp7,9,Nle11] Substance* P (4-11)**	Neurokinin Receptor	Cardiovascular Disease Neurological Disease
[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) is a potent neurokinin NK1 antagonist. [D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) inhibits the effects of gold-protein-substance P (GPSP) and substance P (SP) .

HY-P3880

*(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance* P**	Neurokinin Receptor	Neurological Disease
(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P is a neuropeptide Substance P (HY-P0201) antagonist .

HY-103544

*[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance* P**	JNK Interleukin Related Bombesin Receptor	Inflammation/Immunology Cancer
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P, a Substance P derivative, is a biased agonist toward neuropeptide and chemokine receptors. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P activates G12. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P binds to IL-8 and GRP receptors. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P inhibits ERK-2 activation, activates JNK activity. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P stimulates an increase in neutrophil migration and Ca ²⁺ mobilization. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is also a bombesin antagonist, and inhibits the growth of small cell lung cancer

HY-P1722

Spantide II	Neurokinin Receptor	Inflammation/Immunology
Spantide II, an undecapeptide substance P (SP) analog, is a potent neurokinin-1 receptor (NK-1R) antagonist. Spantide II binds with NK-1R and blocks proinflammatory activities associated with SP. Spantide II can be used in the research of inflammatory skin disorders, such as psoriasis and contact dermatitis .

HY-P3225

*(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance* P acetate**	Peptides	Neurological Disease Inflammation/Immunology
(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P (acetate) is an antagonist for Substance P (HY-P0201) and Bombesin (HY-P0195) that has effects on ocular inflammatory responses to antidromic trigeminal nerve stimulation .

HY-P3850

(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B	Neurokinin Receptor	Neurological Disease
(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B is a competitive antagonist of Neurokinin B (Neurokinin Receptor) with a pA2 of 5.5. (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B shows no influence on Substance P or Neurokinin A .

HY-P1376

G-Protein antagonist peptide	mAChR Adrenergic Receptor	Endocrinology
G-Protein antagonist peptide is the substance P-related peptide that inhibits binding of G proteins to their receptors. G-Protein antagonist peptide competitively and reversibly inhibits M2 muscarinic receptor activation of G_i or G_o and inhibits G_s activation by β-adrenoceptors.

HY-P3801

*[Glp5,(Me)Phe8,Sar9] Substance* P (5-11)** DiMe-C7	Neurokinin Receptor	Others Neurological Disease Metabolic Disease
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats .

Cat. No.	Compare	Product Name	Species	Source

HY-P71712

	Muellerian-inhibiting factor/AMH Protein, Mouse (P.pastoris, His) Amh; Muellerian-inhibiting factor; Anti-Muellerian hormone; AMH; Muellerian-inhibiting Substance; MIS	Mouse	P. pastoris
	Mullerian inhibitory factor (AMH) plays a crucial role in various reproductive processes. It contributes significantly to Mullerian duct degeneration in male fetal sex differentiation. Muellerian-inhibiting factor/AMH Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Muellerian-inhibiting factor/AMH protein, expressed by P. pastoris , with N-His labeled tag. The total length of Muellerian-inhibiting factor/AMH Protein, Mouse (P.pastoris, His) is 103 a.a., with molecular weight of ~24 kDa.

Cat. No.	Product Name	Application	Reactivity

HY-P81130

Substance P Antibody Hs.2563; Neurokinin 1; Neurokinin 2; Neurokinin A; Neurokinin alpha; Neuromedin L; Neuropeptide gamma; NKA; NKNA; PPT; Protachykinin 1 precursor; Substance K; Substance P; TAC1; TAC2; Tachykinin 1; Tachykinin 2; Tachykinin precursor 1; Tachykinin1; TACI; TKN1_HUMAN.	ELISA; IHC-P; IHC-F; Flow-Cyt; ICC; IF	Human, Mouse, Rat, Guinea Pig(predicted: Pig, Cow, Horse, Rabbit, Sheep)
Substance P Antibody is an unconjugated, approximately 1.4/13 kDa, rabbit-derived, anti-Substance P polyclonal antibody. Substance P Antibody can be used for: ELISA, IHC-P, IHC-F, Flow-Cyt, ICC, IF expriments in human, mouse, rat, guinea pig, and predicted: pig, cow, horse, rabbit, sheep background without labeling.

HY-P81073

NK1R Antibody Neurokinin 1; Neurokinin 1 Receptor; NK 1 receptor; NK 1R; NK1 receptor; NK-1R; NK1R; NKIR; SPR; Substance P receptor; TAC 1R; TAC1R; Tachykinin 1 receptor; Tachykinin receptor 1; Tachykinin receptor 1; TACR1; NK1-R; NK1R	WB; ELISA; IHC-P; IHC-F; Flow-Cyt; IF	Human, Rat, Guinea Pig (predicted: Mouse, Dog, Pig, Cow, Horse )
NK1R Antibody is an unconjugated, approximately 48 kDa, rabbit-derived, anti-NK1R polyclonal antibody. NK1R Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, rat, guinea pig, and predicted: mouse, dog, pig, cow, horse background without labeling.

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